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Source – Medicines and Healthcare Products Regulatory Agency (MHRA) – Current problems in pharmacovigilance May 2006 volume 31 highlights the following drugs which are unlicensed for the use in paediatrics but are known to be prescribed off-label
Linezolid (Zyvox▼): severe optic neuropathy – visual function should be routinely monitored in those patients on prolonged (greater
than 28 days) linezolid therapy and evaluated in all patients with new visual symptoms
Drotrecogin alfa (activated) (Xigris▼): risk-benefit in the management of sepsis – adhere to prescribing recommendations
Bisphosphonates: Osteonecrosis of the jaw – osteonecrosis of the jaw has been reported in patients treated with bisphosphonates
Tamsulosin (Flomax) and Intraoperative Floppy Iris Syndrome (IFIS)
For more information go to: http://medicines.mhra.gov.uk/monitorsafequalmed/currentproblems/currentprobl ems.htm
Prepared by Susan Wileman Medicines Information Technician
Date of Preparation: 3rd July 2006
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